根据在线发表于4月27日的《临床药学杂志》上的一项研究，对于患有妊娠期糖尿病的女性来说，日常给予蒿属的提取物与胰岛素敏感性改善有关联。

来自中国青岛市立医院的孙霞和她的队友们测定了蒿属的提取物对患有妊娠期糖尿病的孕妇体内胰岛素抵抗和脂质含量水平的影响。144名处于妊娠第四到六个月的孕妇被随机分成蒿属的提取物组（AE）和安慰剂对照组（PO），她们被指导每天服用这些制剂连续10周。

研究人员发现，与安慰剂对照组相比，在给予蒿属的提取物的治疗组中，作为胰岛素抵抗评价的体内稳态模型中出现了快速血浆葡萄糖降低、血清胰岛素水平降低，以及胰岛β细胞功能降低等。在蒿属的提取物治疗组中，循环中的脂联素的水平显著上调，极大的促进了胰岛素敏感性的改善。

“日常给予蒿属的提取物，主要是通过上调脂联素来改善患有妊娠期糖尿病的孕妇体内的胰岛素的敏感性的。”该研究的作者们如是写道。（来源：来宝网）

Artemisia Extract Improves Insulin Sensitivity in Women With Gestational Diabetes Mellitus by Up-Regulating Adiponectin

Abstract  Gestational diabetes mellitus (GDM) has affected a great number of pregnant women worldwide. Artemisia extracts have been found to exhibit potent anti-diabetic effect in the treatment of type 2 diabetes mellitus. We aimed to examine the effects of Artemisia extract on insulin resistance and lipid profiles in pregnant GDM patients. Patients in their second trimester were randomly assigned to Artemisia extract group (AE) or placebo group (PO). They were instructed to consume either AE of PO daily for a period of 10 weeks. Glucose and insulin profiles and adiponectin level were assessed at baseline (week 0) and after the treatment (week 10). Compared to the PO group, fasting plasma glucose, serum insulin levels, homeostasis model of assessment of insulin resistance (HOMA-IR) and β cell function (HOMA-B) were significantly reduced in AE group participants. Moreover, levels of circulating adiponectin were also significantly up-regulated in the AE group, which also positively contributed to improved insulin sensitivity. Daily administration of Artemisia extract improves insulin sensitivity by up-regulating adiponectin in women with gestational diabetes mellitus.

原文链接：http://onlinelibrary.wiley.com/doi/10.1002/jcph.755/abstract