图：绿原酸延长秀丽隐杆线虫寿命

绿原酸是众多中草药和天然产物中抗菌、抗病毒有效药理成分之一，存在于大量植物中，如茶叶、咖啡、金银花等，具有抗菌、抗病毒、提高白血球、保肝利胆、抗肿瘤、降血压、降血脂、清除自由基和兴奋中枢神经系统等作用。然而，绿原酸对衰老的影响及机制等仍不清楚。

中国科学院昆明植物研究所罗怀容研究组利用秀丽隐杆线虫为模型，发现绿原酸抗衰老作用及其作用机制；研究发现，绿原酸能延长野生型线虫寿命达20.1%；绿原酸主要通过作用于胰岛素信号通路，降低AKT磷酸化水平，激活转录因子DAF-16及其下游基因的表达，提高线虫对外界压力环境的抵抗，延长线虫的寿命。

该研究成果以Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway 为题发表于老年医学专业杂志The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences。

该研究工作得到国家自然科学基金（81370453）和云南省基础研究项目（2013FA045和2015FB172）的资助。（来源：中科院昆明植物研究所）

Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway

Abstract  Coffee and tea, two of the most popular drinks around the world, share many in common from chemical components to beneficial effects on human health. One of their shared components, the polyphenols, most notably chlorogenic acid (CGA), was supposed to account for many of the beneficial effects on ameliorating diseases occurred accompanying people aging, such as the antioxidant effect and against diabetes and cardiovascular disease. CGA is also present in many traditional Chinese medicines. However, the mechanism of these effects was vague. The aging signaling pathways were conservative from yeast and worms to mammals. So, we tested if CGA had an effect on aging in Caenorhabditis elegans. We found that CGA could extend the lifespan of C. elegans by up to 20.1%, delay the age-related decline of body movement, and improve stress resistance. We conducted genetic analysis with a series of worm mutants and found that CGA could extend the lifespan of the mutants of eat-2, glp-1, and isp-1, but not of daf-2, pdk-1, akt-1, akt-2, sgk-1, and clk-1. CGA could activate the FOXO transcription factors DAF-16, HSF-1, SKN-1, and HIF-1, but not SIR-2.1. Taken together, CGA might extend the lifespan of C. elegans mainly via DAF-16 in insulin/IGF-1 signaling pathway.

原文链接：http://biomedgerontology.oxfordjournals.org/content/early/2016/07/04/gerona.glw105.full.pdf+html