李甫
  • 李甫
  • 电子邮件:lifu@cib.ac.cn
  • 职  称:副研究员
  • 学  历:博士研究生
  • 通讯地址:四川省成都市科园南路93号
  • 邮  编:610041

个人简历

  李甫,男,19797月生,江苏徐州人,中国科学院成都生物研究所副研究员 

  教育经历: 

  1999.09-2003.07 江苏师范大学(原徐州师范大学)化学化工学院,获学士学位 

  2003.09-2006.07 广西师范大学化学化工学院,获硕士学位 

  2006.09-2009.07 中国科学院成都生物研究所,获博士学位 

  工作经历: 

  2009.07-2010.01 武汉生物工程学院,讲师 

  2010.05-2012.08中国科学院成都生物研究所,助理研究员 

  2012.09-至今   中国科学院成都生物研究所,副研究员 

研究方向

  药用植物或药食同源植物次级代谢产物的提取、分离、结构鉴定和生物活性,重点关注新的天然多糖或糖苷类化合物(皂苷、黄酮苷等)的结构和功能。 

社会任职

 

获奖及荣誉

 

承担科研项目情况

  1. 中科院重要方向项目子课题蔷薇花果化学成分的空间差异与高值成分筛选” 2011-2013 

  2. 四川省科技支撑计划紫薯功能性成分的研究” 2012-2014 

  3. 国家重点研发计划子课题植物健康饮品生产工艺技术研发” 2017-2020 

代表论著

  论文(第一或通讯作者): 

  [1]       Xia Zhang, Lun Wang, Fan Xie, Aftab Yaseen, Bin Chen, Guolin Zhang, Mingkui Wang, Xiaofei Shen*, Fu Li*. A polysaccharide TKP-2-1 from Tamarindus indica L: Purification, structural characterization and immunomodulating activity. Journal of Functional Foods, 2021, 78: 104384. 

  [2]       Yanyan Luo, Yunyao Jiang, Yang He, Ting Shen, Lilian Ji, Fu Li*, Weicheng Hu*. Vina-Ginsenoside R4 from Panax ginseng Leaves Alleviates 6-OHDA-Induced Neurotoxicity in PC12 Cells Via the PI3K/Akt/GSK-3 Signaling Pathway. Journal of Agricultural and Food Chemistry, 2020, 68: 15239-15248. 

  [3]       Zhouwei Wu#, Weibo Li#, Jing Zhou, Xin Liu, Lun Wang, Bin Chen, Mingkui Wang, Lilian Ji, Weicheng Hu*, Fu Li*. Oleanane- and Ursane-Type Triterpene Saponins from Centella asiatica Exhibit Neuroprotective Effects, Journal of Agricultural and Food Chemistry, 2020, 68: 6977-6986. 

  [4]       Donghai Chu#, Aftab Yaseen#, Lun Wang, Bin Chen, Mingkui Wang, Weicheng Hu*, Fu Li*. Two New Cucurbitane Glycosides from the Fruits of Siraitia grosvenori, Chemical & Pharmaceutical Bulletin, 2019, 67 (7), 721-724. 

  [5]       Li Fu#, Cao Yufeng#, Luo Yanyan#, Liu Tingwu, Yan Guilong, Chen Liang, Ji Lilian, Wang Lun, Chen Bin, Yaseen Aftab, Khan Ashfaq Ahmad, Zhang Guolin, Jiang Yunyao, Liu Jianxun, Wang Gongcheng*, Wang Mingkui*, Hu Weicheng*. Two new triterpenoid saponins derived from the leaves of Panax ginseng and their antiinflammatory activity, Journal of Ginseng Research, 2019, 43(4):600-605. 

  [6]       Weicheng Hu#, Yunyao Jiang#, Qi Xue, Fengting Sun, Jianmei Zhang, Jing Zhou, Zhiqiang Niu, Qiuting Li, Weibo Li, Fu Li*, Ting Shen*. Structural characterisation and immunomodulatory activity of a polysaccharide isolated from lotus (Nelumbo nucifera Gaertn.) root residues, Journal of Functional Foods, 2019, 60:103457. 

  [7]       Yu-Feng Cao#, Fu Li#, Yan-Yan Luo#, Liang Zhang, Shu-Ya Lu, Rui Xing, Bing-Jun Yan, Hong-Yin Zhang*, Wei-Cheng Hu*, 20-Hydroxy-3-oxolupan-28-oic acid attenuates inflammatory responses by regulating PI3K–Akt and MAPKs signaling pathways in LPS-Stimulated RAW264.7 macrophages, Molecules, 2019, 24(3), 386. 

  [8]       Xi-Lan Jiang, Lun Wang*, En-Jun Wang, Guo-Lin Zhang, Bin Chen, Ming-Kui Wang, Fu Li*, Flavonoid glycosides and alkaloids from the embryos of Nelumbo nucifera seeds and their antioxidant activity, Fitoterapia, 2018, 125:184-190. 

  [9]       Yu-Jing Feng#, Zhou-Wei Wu#, Yan-Yan Luo, Liang Chen, Yu-Feng Cao, Lun Wang, Aftab Yaseen, Bin Chen, Ashfaq Ahmad Khan, Ming-Kui Wang, Guo-Lin Zhang, Xin-Feng Wang*, Fu Li*, Xue-Qin Li, Wei-Cheng Hu*. A new triterpene diglycoside from the roots of Bupleurum chinense DC. and its inhibitory effect on adipogensis in 3T3-L1 cells. Medicinal Chemistry Research, 2019, 28:239-245. 

  [10]    Lun Wang, Xi-Lan Jiang, Wen-Ming Zhang, Fu Li*, Ashfaq-Ahmad Khan, Xin Liu, Kai Yu, Ming-Kui Wang*, Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicas, Phytochemistry, 2017, 136: 125-132. 

  [11]    Fu Li, Fu-mei Yang, Xin Liu, Lun Wang, Bin Chen, Lian-hong Li, Ming-kui Wang*, Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro, Food Chemistry, 2017, 228: 567-573. 

  [12]    Fu Li#, Bao-Wen Du#, Dan-Feng Lu#, Wen-Xuan Wu, Kanjana Wongkrajang, Lun Wang, Wen-Chen Pu, Chang-Lu Liu, Han-Wei Liu, Ming-Kui Wang*, Fei Wang*, Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects, Scientific Reports, 2017, 7: 1-12. 

  [13]    Jia-You Sun, Lun Wang, Ming-Kui Wang, Zhi-Zhong Wang*, Fu Li*, Two new polyacetylene glycosides from the roots of Codonopsis tangshen Oliv., Natural Product Research, 2016, 30(20): 2338-2343. 

  [14]    Xiao-Long Zhang , Ashfaq-Ahmad Khan, Lun Wang, Kai Yu, Fu Li*, Ming-Kui Wang*, Four new phorbol diesters from Croton tiglium and their cytotoxic activities, Phytochemistry Letters, 2016, 16: 82-86. 

  [15]    Wen-Jun He, Chun-Yan Yang, Ming-Kui Wang, Fu Li*, A novel phenolic acid from the fruits of Rosa soulieana, Natural Product Research, 2014, 28(15): 1127-1133. 

  [16]    Fu Li, Hong-Mei Pan, Xin Liu, Bin Chen, Ya-Xiong Tang, Xing-Jun Xi, Ming-Kui Wang*, New phenanthrene glycosides from Dendrobium denneanum and their cytotoxic activity. Phytochemistry Letters, 2013, 6 (4): 640-644. 

  [17]    Xiao-Qiang Zhang, Fu Li*, Zhi-Gang Zhao, Xing-Li Liu, Ya-Xiong Tang, Ming-Kui Wang, Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities. Phytochemistry Letters, 2012, 5(2):721-724. 

  [18]    Fu Li, Xin Liu, Ming-Hai Tang, Bin Chen, Li-Sheng Ding, Li-Juan Chen, Ming-Kui Wang*, Structure revision of hupehensis saponin F and G and characterization of new trace triterpenoid saponins from Anemone hupehensis by tandem electrospray ionization mass spectrometry. Carbohydrate Research, 2012, 353:49-56. 

  [19]    Fu Li, Cui-Rong Sun, Bin Chen, Li-Sheng Ding, Ming-Kui Wang*, Triterpenoid saponins from Anemone raddeana. Phytochemistry Letters, 2012, 5(2):258-261. 

  [20]    Jun Li*, Fu Li, Yuan-Yuan Lu, Xiao-Jian Su, Cui-Ping Huang, Xue-Wen Lu. A new dilactone from the seeds of Gaultheria yunnanensis, Fitoterapia, 2010, 81 (1) : 35-37. 

  [21]    Fu Li, Li-Sheng Ding, Ming-Kui Wang*, A new triterpenoid saponin from Anemone raddeana. Chinese Chemical Letters, 2008, 19 (3):305-307. 

  [22]    李甫,徐凯节,丁立生,王明奎*,硅胶柱层析-电喷雾多级质谱快速分析中药两头尖中的三萜皂苷类成分,分析化学2011, 39 (2):219-224. 

  [23]    王明奎*李甫,一个环硫乙烷中间体的合成,有机化学, 2008, 28(8):1471- 1474. 

  授权专利: 

  [1] 王明奎,崔文峰,鲍玲,李甫. 粉防己生物碱的制备工艺, 专利号ZL200710048865.5 

  [2] 晏菊芳,王明奎,李甫,张蔚瑜,陈欣. 一种三萜皂甙衍生物及其制备方法和用途,专利号ZL200910060122.9 

  [3] 王明奎,李甫,杨春艳,陈斌. 一种蔷薇花茶、其制备方法和用途,专利号ZL201310664153.1 

  [4] 李甫,苏剑君,王明奎. 一种有效保湿、祛痘和抗衰老的植物多糖组合物及其制备方法和应用,专利号ZL201510618498.2