- 李甫
- 电子邮件:lifu@cib.ac.cn
- 职 称:副研究员
- 学 历:博士研究生
- 通讯地址:四川省成都市科园南路93号
- 邮 编:610041
个人简历
李甫,男,1979年7月生,江苏徐州人,中国科学院成都生物研究所副研究员
教育经历:
1999.09-2003.07 江苏师范大学(原徐州师范大学)化学化工学院,获学士学位
2003.09-2006.07 广西师范大学化学化工学院,获硕士学位
2006.09-2009.07 中国科学院成都生物研究所,获博士学位
工作经历:
2009.07-2010.01 武汉生物工程学院,讲师
2010.05-2012.08中国科学院成都生物研究所,助理研究员
2012.09-至今 中国科学院成都生物研究所,副研究员
研究方向
药用植物或药食同源植物次级代谢产物的提取、分离、结构鉴定和生物活性,重点关注新的天然多糖或糖苷类化合物(皂苷、黄酮苷等)的结构和功能。
社会任职
获奖及荣誉
承担科研项目情况
1. 中科院重要方向项目子课题“蔷薇花果化学成分的空间差异与高值成分筛选” 2011-2013
2. 四川省科技支撑计划“紫薯功能性成分的研究” 2012-2014
3. 国家重点研发计划子课题“植物健康饮品生产工艺技术研发” 2017-2020
代表论著
论文(第一或通讯作者):
[1] Xia Zhang, Lun Wang, Fan Xie, Aftab Yaseen, Bin Chen, Guolin Zhang, Mingkui Wang, Xiaofei Shen*, Fu Li*. A polysaccharide TKP-2-1 from Tamarindus indica L: Purification, structural characterization and immunomodulating activity. Journal of Functional Foods, 2021, 78: 104384.
[2] Yanyan Luo, Yunyao Jiang, Yang He, Ting Shen, Lilian Ji, Fu Li*, Weicheng Hu*. Vina-Ginsenoside R4 from Panax ginseng Leaves Alleviates 6-OHDA-Induced Neurotoxicity in PC12 Cells Via the PI3K/Akt/GSK-3 Signaling Pathway. Journal of Agricultural and Food Chemistry, 2020, 68: 15239-15248.
[3] Zhouwei Wu#, Weibo Li#, Jing Zhou, Xin Liu, Lun Wang, Bin Chen, Mingkui Wang, Lilian Ji, Weicheng Hu*, Fu Li*. Oleanane- and Ursane-Type Triterpene Saponins from Centella asiatica Exhibit Neuroprotective Effects, Journal of Agricultural and Food Chemistry, 2020, 68: 6977-6986.
[4] Donghai Chu#, Aftab Yaseen#, Lun Wang, Bin Chen, Mingkui Wang, Weicheng Hu*, Fu Li*. Two New Cucurbitane Glycosides from the Fruits of Siraitia grosvenori, Chemical & Pharmaceutical Bulletin, 2019, 67 (7), 721-724.
[5] Li Fu#, Cao Yufeng#, Luo Yanyan#, Liu Tingwu, Yan Guilong, Chen Liang, Ji Lilian, Wang Lun, Chen Bin, Yaseen Aftab, Khan Ashfaq Ahmad, Zhang Guolin, Jiang Yunyao, Liu Jianxun, Wang Gongcheng*, Wang Mingkui*, Hu Weicheng*. Two new triterpenoid saponins derived from the leaves of Panax ginseng and their antiinflammatory activity, Journal of Ginseng Research, 2019, 43(4):600-605.
[6] Weicheng Hu#, Yunyao Jiang#, Qi Xue, Fengting Sun, Jianmei Zhang, Jing Zhou, Zhiqiang Niu, Qiuting Li, Weibo Li, Fu Li*, Ting Shen*. Structural characterisation and immunomodulatory activity of a polysaccharide isolated from lotus (Nelumbo nucifera Gaertn.) root residues, Journal of Functional Foods, 2019, 60:103457.
[7] Yu-Feng Cao#, Fu Li#, Yan-Yan Luo#, Liang Zhang, Shu-Ya Lu, Rui Xing, Bing-Jun Yan, Hong-Yin Zhang*, Wei-Cheng Hu*, 20-Hydroxy-3-oxolupan-28-oic acid attenuates inflammatory responses by regulating PI3K–Akt and MAPKs signaling pathways in LPS-Stimulated RAW264.7 macrophages, Molecules, 2019, 24(3), 386.
[8] Xi-Lan Jiang, Lun Wang*, En-Jun Wang, Guo-Lin Zhang, Bin Chen, Ming-Kui Wang, Fu Li*, Flavonoid glycosides and alkaloids from the embryos of Nelumbo nucifera seeds and their antioxidant activity, Fitoterapia, 2018, 125:184-190.
[9] Yu-Jing Feng#, Zhou-Wei Wu#, Yan-Yan Luo, Liang Chen, Yu-Feng Cao, Lun Wang, Aftab Yaseen, Bin Chen, Ashfaq Ahmad Khan, Ming-Kui Wang, Guo-Lin Zhang, Xin-Feng Wang*, Fu Li*, Xue-Qin Li, Wei-Cheng Hu*. A new triterpene diglycoside from the roots of Bupleurum chinense DC. and its inhibitory effect on adipogensis in 3T3-L1 cells. Medicinal Chemistry Research, 2019, 28:239-245.
[10] Lun Wang, Xi-Lan Jiang, Wen-Ming Zhang, Fu Li*, Ashfaq-Ahmad Khan, Xin Liu, Kai Yu, Ming-Kui Wang*, Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicas, Phytochemistry, 2017, 136: 125-132.
[11] Fu Li, Fu-mei Yang, Xin Liu, Lun Wang, Bin Chen, Lian-hong Li, Ming-kui Wang*, Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro, Food Chemistry, 2017, 228: 567-573.
[12] Fu Li#, Bao-Wen Du#, Dan-Feng Lu#, Wen-Xuan Wu, Kanjana Wongkrajang, Lun Wang, Wen-Chen Pu, Chang-Lu Liu, Han-Wei Liu, Ming-Kui Wang*, Fei Wang*, Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects, Scientific Reports, 2017, 7: 1-12.
[13] Jia-You Sun, Lun Wang, Ming-Kui Wang, Zhi-Zhong Wang*, Fu Li*, Two new polyacetylene glycosides from the roots of Codonopsis tangshen Oliv., Natural Product Research, 2016, 30(20): 2338-2343.
[14] Xiao-Long Zhang , Ashfaq-Ahmad Khan, Lun Wang, Kai Yu, Fu Li*, Ming-Kui Wang*, Four new phorbol diesters from Croton tiglium and their cytotoxic activities, Phytochemistry Letters, 2016, 16: 82-86.
[15] Wen-Jun He, Chun-Yan Yang, Ming-Kui Wang, Fu Li*, A novel phenolic acid from the fruits of Rosa soulieana, Natural Product Research, 2014, 28(15): 1127-1133.
[16] Fu Li, Hong-Mei Pan, Xin Liu, Bin Chen, Ya-Xiong Tang, Xing-Jun Xi, Ming-Kui Wang*, New phenanthrene glycosides from Dendrobium denneanum and their cytotoxic activity. Phytochemistry Letters, 2013, 6 (4): 640-644.
[17] Xiao-Qiang Zhang, Fu Li*, Zhi-Gang Zhao, Xing-Li Liu, Ya-Xiong Tang, Ming-Kui Wang, Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities. Phytochemistry Letters, 2012, 5(2):721-724.
[18] Fu Li, Xin Liu, Ming-Hai Tang, Bin Chen, Li-Sheng Ding, Li-Juan Chen, Ming-Kui Wang*, Structure revision of hupehensis saponin F and G and characterization of new trace triterpenoid saponins from Anemone hupehensis by tandem electrospray ionization mass spectrometry. Carbohydrate Research, 2012, 353:49-56.
[19] Fu Li, Cui-Rong Sun, Bin Chen, Li-Sheng Ding, Ming-Kui Wang*, Triterpenoid saponins from Anemone raddeana. Phytochemistry Letters, 2012, 5(2):258-261.
[20] Jun Li*, Fu Li, Yuan-Yuan Lu, Xiao-Jian Su, Cui-Ping Huang, Xue-Wen Lu. A new dilactone from the seeds of Gaultheria yunnanensis, Fitoterapia, 2010, 81 (1) : 35-37.
[21] Fu Li, Li-Sheng Ding, Ming-Kui Wang*, A new triterpenoid saponin from Anemone raddeana. Chinese Chemical Letters, 2008, 19 (3):305-307.
[22] 李甫,徐凯节,丁立生,王明奎*,硅胶柱层析-电喷雾多级质谱快速分析中药两头尖中的三萜皂苷类成分,分析化学,2011, 39 (2):219-224.
[23] 王明奎*,李甫,一个环硫乙烷中间体的合成,有机化学, 2008, 28(8):1471- 1474.
授权专利:
[1] 王明奎,崔文峰,鲍玲,李甫. 粉防己生物碱的制备工艺, 专利号ZL200710048865.5
[2] 晏菊芳,王明奎,李甫,张蔚瑜,陈欣. 一种三萜皂甙衍生物及其制备方法和用途,专利号ZL200910060122.9
[3] 王明奎,李甫,杨春艳,陈斌. 一种蔷薇花茶、其制备方法和用途,专利号ZL201310664153.1
[4] 李甫,苏剑君,王明奎. 一种有效保湿、祛痘和抗衰老的植物多糖组合物及其制备方法和应用,专利号ZL201510618498.2