青琳森
  • 青琳森
  • 电子邮件:qingls@cib.ac.cn
  • 职  称:研究员
  • 学  历:博士研究生

个人简历

  青琳森,男,1981年9月生,四川南充人,执业药师,研究员、博士生导师

  教育经历:

  1999.9 - 2003.6  华西医科大学,药学院,药学专业本科 

  2003.9 - 2006.6  四川大学,华西药学院,生药学专业硕士 

  2008.9 - 2011.6  中国科学院成都生物研究所,药物化学专业博士 

  工作经历:

  2006.7 - 2008.8  成都地奥制药集团,药物研究所 

  2011.7 - 2013.6  中国科学院成都生物研究所,博士后 

  2013.7至今       中国科学院成都生物研究所,副研究员、研究员

研究方向

  天然活性成分研究与新药开发 

社会任职

  四川省药学会中药与天然药专委会委员

  四川省分析测试学会有机质谱专委会理事

  中国人民政治协商会议成都市第十六届委员会委员

获奖及荣誉

承担科研项目情况

  主持: 

  1. 中央引导地方科技发展资金项目,2022.9-2023.8 

  2. 四川省科技计划国际/港澳台科技创新合作项目,2022.1-2023.12 

  3. 中国科学院战略生物资源服务网络计划活性天然化合物发现、评价与转化平台项目,2021.10-2024.12 

  4. 浙江佐力药业股份有限公司委托项目,2021.3-2024.3 

  5. 四川省科技计划重点研发项目,2019.1-2020.12 

  6. 中国科学院西部青年学者(院内A类)项目,2019.1-2021.12 

  7. 中国科学院战略生物资源服务网络计划活性天然化合物发现、评价与转化平台项目,2018.8-2021.7 

  8. 中国博士后科学基金第6批特别资助,2013.6-2016.6 

  9. 中国科学院西部博士人才培养计划,2013.1-2016.6 

  10. 国家自然科学基金青年基金,2013.1-2015.12 

  11. 中国博士后科学基金第50批面上资助,2011.9-2013.12 

  同时参与国家自然科学基金、四川省科技计划、香港特区政府卫生署项目、澳门科学技术发展基金等多项课题的研究。 

代表论著

  科研论文(一作/通讯,含并列):


1. Xiao-Feng Huang, et al. Chemical derivatization strategies for enhancing HPLC analytical performance of natural active triterpenoids. Journal of Pharmaceutical Analysis. 2024, 14(3): 295-307.

2. Xiao-Yi Chen, et al. Preclinical investigations on anti-fibrotic potential of long-term oral therapy of sodium astragalosidate in animal models of cardiac and renal fibrosis. ACS Pharmacology & Translational Science. 2024, 7(2): 421-431.

3. Shan-Shan Song, et al. Role of simulated in vitro gastrointestinal digestion on biotransformation and bioactivity of astragalosides from Radix Astragali, Journal of Pharmaceutical and Biomedical Analysis, 2023, 231: 115414.

4. Qian-Long Wang, et al. Surface hydrolysis-designed AuNPs-zwitterionic-glucose as a novel tool for targeting macrophage visualization and delivery into infarcted hearts, Journal of Controlled Release, 2023, 356: 678-690.

5. Lin-Sen Qing, et al. Microfluidic strategies for natural products in drug discovery: Current status and future perspectives. Trends in Analytical Chemistry, 2023, 158: 116832.

6. You-Jiao Wu, et al. Elucidation of the binding mechanism of astragaloside IV derivative with human serum albumin and its cardiotoxicity in zebrafish embryos. Frontiers in Pharmacology, 2022, 13: 987882.

7. Tian-Tian Wang, et al. Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review. Advanced Sensor and Energy Materials, 2022, 1(3): 100016.

8. Qian-Long Wang, et al. Non-invasion prognosis of post-myocardial infarction using urinary miRNA ultra-trace detection based on single target DNA functionalized AuNPs. ACS Applied Materials & Interfaces, 2022, 14(3): 3633-3642.

9. Ming-Qing Tang, et al. Advances in aptamer-based sensing assays for C-reactive protein. Analytical and Bioanalytical Chemistry, 2022, 414(2): 867-884.

10. Jing Xie, et al. Determination of nine nucleosides in Rhizoma Paridis by quantitative analysis of multi-components via a single marker method. Journal of Separation Science, 2021, 44(9): 1866-1874.

11. Li Chen, et al. Astragaloside IV derivative (LS-102) alleviated myocardial ischemia reperfusion injury by inhibiting Drp1Ser616 phosphorylation-mediated mitochondrial fission. Frontiers in Pharmacology, 2020, 11: 1083.

12. Ming-Qing Tang, et al. Research progress of C-reactive protein analysis. Chinese Journal of Analytical Chemistry, 2020, 48(9): 1121-1130.

13. Tian-Tian Wang, et al. A feasible image-based colorimetric assay using a smartphone RGB camera for point-of-care monitoring of diabetes. Talanta, 2020, 206: 120211.

14. Qian-Long Wang, et al. Colorimetric determination of the early biomarker hypoxia-inducible factor-1 alpha (HIF-1 ) in circulating exosomes by using a gold seed-coated with aptamer-functionalized Au@Au core-shell peroxidase mimic. Microchimica Acta, 2020, 187(1): 61.

15. Chao-Xi Chen, et al. A new strategy for the preparation of antibody against natural glycoside: With astragaloside IV as an example. Fitoterapia, 2020, 142: 104488.