- 罗应刚
- 电子邮件：yinggluo@cib.ac.cn
- 职 称：研究员
- 学 历：博士研究生
- 通讯地址：成都市人民南路四段9号
- 邮 编：610041
个人简历
1993.9——1997.7 西南师范大学生命科学学院,获理学学士学位，生物学专业。
1997.7——2000.7 中国科学院成都生物研究所天然产物研究中心,从事天然药物化学研究，获理学硕士学位，植物学专业。
2000.9——2003.7 中国科学院成都有机化学研究所，从事有机化学、药物化学研究，获理学博士学位，有机化学专业。
2003.7——现 在 中国科学院成都生物研究所天然产物研究中心，从事有机化学、药物化学研究，助理研究员、副研究员。
2007.4——2008.4 美国威斯康星大学麦迪逊分校(School of Pharmacy, University of Wisconsin-Madison)，从事次级代谢产物的组合生物合成与酶促生化反应研究，访问学者
研究方向
药物生物合成与合成生物学
社会任职
获奖及荣誉
承担科研项目情况
主持国家自然科学、中国科学院、四川省和成都市及企业合作项目等各类科研项目20余项。
代表论著
1. Yi Li, Xuefei Wang, Zhan Liu, Yun Yang, Liangzhen Jiang, Xixing Qu, Xiang Pu, Yinggang Luo*. Regioselective O-acetylation of various glucosides catalyzed by Escherichia coli maltose O-acetyltransferase. Applied Microbiology and Biotechnology 2023, 107, 7031-7042.
2. Daijing Wei, Yun Yang, Ruiying Xi, Yunqing He, Ighodaro Igbe, Wei Wang, Guolin Zhang*, Yinggang Luo*. Hunteriasines A – D, tryptamine-derived alkaloids from Hunteria umbellata. Phytochemistry 2023, 213, 113752.
3. Zhan Liu, Yi Li, Daijing Wei, Jing Wang, Chong Qiao, Guo-you Li, Guolin Zhang and Yinggang Luo*. Biosensor-enabled discovery of CaERG6 inhibitors and their antifungal mode of action against Candida albicans. ACS Infectious Diseases 2023, 9, 785-800.
4. Chong Qiao, Fei Chen, Zhan Liu, Tianfang Huang, Wei Li, Guolin Zhang, Yinggang Luo*. Functional characterization of a catalytically promiscuous tryptophan decarboxylase from camptothecin-producing Camptotheca acuminata. Frontiers in Plant Science 2022, 13, 987348.
5. Xuejian Zhang, Yu Cao, Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang*, and Yinggang Luo*. Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa. Phytochemistry 2022, 203, 113378.
6. Xuejian Zhang, Guoyong Luo, Yu Cao, Dumaa Mishig, Munkhgerel Lodonjav, Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang,* and Yinggang Luo*. ( )-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa. Bioorganic Chemistry 2021, 116, 105364.
7. Liangzhen Jiang, Jing Pang, Lixia Yang, Wei Li, Lili Duan, Guolin Zhang, Yinggang Luo*. Engineering endogenous L-proline biosynthetic pathway to boost trans-4-hydroxy-L-proline production in Escherichia coli. Journal of Biotechnology 2021, 329, 104-117.
8.Xuejian Zhang, Ting Peng, Xiaoke Shi, Dongmei, Fang, Lin Tang, Fang Chen, Fei Wang,Guolin Zhang*, YinggangLuo*. Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa. Phytochemisty 2020, 180, 112534.
9. Annoor Awadasseid, Wei Li, Zhan Liu, Chong Qiao, Jing Pang, Guolin Zhang, Yinggang Luo*. Characterization of Camptotheca acuminata 10-hydroxygeraniol oxidoreductase and iridoid synthase and their application in biological preparation of nepetalactol in Escherichia coli featuring NADP+ - NADPH cofactors recycling. International Journal of Biological Macromolecules 2020, 162, 1076-1085.
10. Yun Yang, Wei Li, Jing Pang, Liangzhen Jiang, Xixing Qu, Xiang Pu, Guolin Zhang, and Yinggang Luo*. Bifunctional cytochrome P450 enzymes involved in camptothecin biosynthesis. ACS Chemical Biology 2019, 14, 1091-1096.
11. Wei Li, Chong Qiao, Jing Pang, Guolin Zhang, Yinggang Luo*. The versatile O-methyltransferase LrOMT catalyzes multiple O-methylation reactions in Amaryllidaceae alkaloid biosynthesis. International Journal of Biological Macromolecules 2019, 141, 680-692.
12. Jinzhi Zhao, Yun Yang, Mengyao Yu, Ke Yao, Xia Luo, Huayi Qi, Guolin Zhang*, and Yinggang Luo*. Lanostane-type C31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris. Phytochemistry 2018, 152, 10-21.
13. Wei Li, Yun Yang, Chong Qiao, Guolin Zhang, and Yinggang Luo*. Functional characterization of phenylalanine ammonia-lyase- and cinnamate 4-hydroxylase-encodiing genes from Lycoris radiata, a galanthamine-producing plant. International Journal of Biological Macromolecules, 2018, 117, 1264-1279.
14. Lixia Yang, Liangzhen Jiang, Wei Li, Yun Yang, Guolin Zhang, and Yinggang Luo*. A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial application in geraniol production in Escherichia coli. Journal of Industrial Microbiology & Biotechnology 2017, 44 (10), 1431-1441.
15. Yun Yang, Xiang Pu, Xixing Qu, Fei Chen, Guolin Zhang, and Yinggang Luo*. Enhanced production of camptothecin and biological preparation of N1-acetylkynuramine in Camptotheca acuminata cell suspension cultures. Applied Microbiology and Biotechnology 2017, 101 (10), 4053-4062.
16. Fei Chen, Wei Li, Liangzhen Jiang, Xiang Pu, Yun Yang, Guolin Zhang, and Yinggang Luo*. Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminata and its application in the production of geraniol in Escherichia coli. Journal of Industrial Microbiology & Biotechnology 2016, 43 (9), 1281-1292.
17. Guoyong Luo, Qi Ye, Baowen Du, Fei Wang, Guolin Zhang*, and Yinggang Luo*. Iridoid glucosides and diteropenoids from Caryopteris glutinosa. Journal of Natural Products 2016, 79 (4), 886-893.
18. Xiang Pu, Fei Chen, Yun Yang, Xixing Qu, Guolin Zhang, and Yinggang Luo*. Isolation and characterization of Paenibacillus polymyxa LY214, a camptothecin-producing endophytic bacterium from Camptotheca acuminata. Journal of Industrial Microbiology & Biotechnology 2015, 42, 1197-1202.
19. Xixing Qu, Xiang Pu, Fei Chen, Yun Yang, Lixia Yang, Guolin Zhang, and Yinggang Luo*. Molecular cloning, heterologous expression, and functional characterization of an NADPH-cytochrome P450 reductase gene from Camptotheca acuminata, a camptothecin-producing plant. PLoS ONE 2015, 10 (8), e0135397. doi: 10.1371/journal.pone.0135397.
20. Yinggang Luo*, Xiang Pu, Guoyong Luo, Min Zhou, Qi Ye, Yan Liu, Jian Gu, Huayi Qi, Guo-you Li, and Guo-lin Zhang*. Nitrogen-containing Dihydro-b-agarofuran Derivatives from Tripterygium wilfordii. Journal of Natural Products 2014, 77 (7), 1650-1657.
21. Xiang Pu, Xixing Qu, Fei Chen, Jinku Bao, Guolin Zhang*, and Yinggang Luo*. Camptothecin-producing Endophytic Fungus Trichoderma atroviride LY357: Isolation, Identification, and Fermentation Conditions Optimization for Camptothecin Production. Applied Microbiology and Biotechnology 2013, 97 (21), 9365-9375.
22. Shou-Zheng Tian, Xiang Pu, Guoyong Luo, Li-Xing Zhao, Li-Hua Xu, Wen-Jun Li, and Yinggang Luo*. Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087. Journal of Agricultural and Food Chemistry 2013, 61 (12), 3006-3012.
23. Yinggang Luo, Min Zhou, Qi Ye, Qiang Pu, and Guolin Zhang*. Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii. Journal of Natural Products 2012, 75 (1), 98-102.
24. Yinggang Luo*, Guangzhou Li, Guoyou Li, Jufang Yan, Jinhai Yi, and Guolin Zhang. Discovery and identification of 2-phenylethyl 2,6-dihydroxybenzoate as a natural lipid-lowering lead. Planta Medica 2011, 77 (18), 2047-2049.
25. Jianya Ling, Geoffrey P. Horsman, Sheng-Xiong Huang, Yinggang Luo, Shuangjun Lin, and Ben Shen*. Enediyne Antitumor Antibiotic Maduropeptin Biosynthesis Featuring a C-Methyltransferase That Acts on a CoA-Tethered Aromatic Substrate. Journal of the American Chemical Society 2010, 132 (36), 12534-12536.
26. Yinggang Luo, Wenli Li, Jianhua Ju, Qiuping Yuan, Noel R. Peters, F. Michael Hoffmann, Sheng-Xiong Huang, Tim S. Bugni, Scott Rajski, Hiroyuki Osada and Ben Shen*. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. Journal of the American Chemical Society 2010, 132 (19), 6663-6671.
27. Wenli Li, Yinggang Luo, Jianhua Ju, Scott R. Rajski, Hiroyuki Osada, and Ben Shen*. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. Journal of Natural Products 2009, 72 (3), 450-459.
28. Yinggang Luo, Shuangjun Lin, Jian Zhang, Heather A. Cooke, Steven D. Bruner, and Ben Shen*. Regiospecific O-Methylation of Naphthoic Acids Catalyzed by NcsB1, an O-Methyltransferase Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin. The Journal of Biological Chemistry 2008, 283, 14694-14702.
