采用化学生物学的原理与方法，发现与肿瘤、炎症等疾病相关的JAK/STAT，雌激素的生物合成和代谢，microRNA生物合成、炎症小体等信号通路的天然产物化学小分子，研究其构效关系，以活性小分子为探针研究其作用机制，以期发现新的信号调控机制以及具有诊疗作用的药物前体和药物靶点。 

分别主持： 

　　《化学小分子调节RNAi信号途径》，中科院成都生物所领域前沿项目， 2008-2010. 

　　《雌激素诱导的细胞膜表面结合的雌激素受体 的动态变化和信号终止机制研究》，国家自然科学基金青年科学基金项目，批准号：30900769， 2010.01-2012.12. 

　　《调控干扰素信号途径的化学小分子的筛选和功能鉴定》，中国科学院院长特别奖获得者项目启动基金（2009.01-2011.12）和教育部留学回国人员启动基金（2009.01-2009.12）. 

　　《女贞子的综合利用与开发》，中国科学院“西部之光”重点项目（2009.01-2012.12）及后续择优项目（2013.01-2014.12）. 

　　《蛋白激酶A介导的磷酸化调控芳香化酶降解机制的化学生物学研究》，国家自然科学基金面上项目，批准号：21372214，2014.01-2017.12. 

　　《基于共轭聚合物纳米粒子的蛋白质-蛋白质相互作用药物筛选新方法的研究及其应用》，中科院“西部之光”联合学者项目，2014.01-2016.12. 

　　《 7尼古丁乙酰胆碱受体激动剂治疗类风湿性关节炎的研究》，四川省科技厅国际合作项目，批准号：2016HH0073，2016.01-2017.12. 

　　《苯基噁唑类化合物通过TRBP调控microRNA生物合成抑制肝癌转移的化学生物学研究》，国家自然科学基金面上项目，批准号：21672207， 2017.01-2020.12. 

　　《二苯庚烷类化合物作为 7尼古丁乙酰胆碱受体激动剂治疗心律失常的研究》,中国科学院, 批准号：ZSTH-004, 2016.09-2018.06. 

　　 《黄烷酮类小分子靶向蛋白酪氨酸磷酸酶SHP2调控RAS信号通路抑制肺癌的化学生物学研究》，国家自然科学基金面上项目，批准号：219770927，2020.01-2023.12. 

　　《治疗多囊卵巢综合症的芳香化酶抑制剂天然药物的发现及研究》，四川省科技厅国际合作项目，批准号：2021YFH0079，2021.04-2023.3.31. 

    《环己烯基异硫氰酸酯类共价抑制剂靶向caspase-1调控其活性和底物识别特异性的化学生物学研究》国家自然科学基金面上项目 批准号：22177110 直接经费60万 2022.01-2025.12  

    作为项目主要研究人员，参与包括科技部973计划，国家自然科学基金重点项目和重大研究计划“基于化学小分子探针的信号转导过程研究”等国家级课题的研究。

　（*表示通讯作者） 

　　1. Junli Zhou, Fei Wang, Wenshi Ma, Yansheng Zhang, Bin Han, Yongbiao Xue. Structural and transcriptional analysis of S-locus F-box genes in Antirrhinum.  Sexual Plant Reproduction 2003, 16:165-177. 

　　2. Hong Qiao*, Fei Wang*, Lan Zhao*, Junli Zhou, Zhao Lai, Yansheng Zhang, Timothy P. Robbins, and Yongbiao Xue, The F-box protein AhSLF-S2 controls the pollen function of S-RNase-based self-incompatibility, Plant Cell, 2004, 16:2307-2322. (* equal contribution)  

　　3. 杨笛笑，李麒麟，张国林，王飞，齐墩果醇-龙胆三糖苷雌激素样作用及其对肝癌HepG2细胞增殖的影响，天然产物研究与开发，2010，22:697-700  

　　4. 王玉梅，陈前锋，杨莉娟，王飞， 女贞子对大鼠成骨细胞增殖与分化的影响，天然产物研究与开发，2011，23(2):232-235  

　　5. Lijuan Yang, Qianfeng Chen, Fei Wang*, Guolin Zhang*, Antiosteoporotic compounds from seeds of Cuscuta chinensis, Journal of Ethnopharmacology, 2011, 135:553-560. (* co-corresponding author)  

　　6. Wenchen Pu, Fei Wang, Chun Wang, Bioactivities and synthetic methods of 2-arylbenzo[b]furans, Chinese Journal of Organic Chemistry, 2011, 31:155-165  

　　7. Xing Wang, Guangyin Lv， Lijuan Yang, Fei Wang, Chun Wang, Synthesis and selective estrogen receptor binding affinity of 7-hydroxylisoflavones, Chinese Journal of Organic Chemistry, 2011, 31:1245-1251.  

　　8. Zhengfu Tai, Guolin Zhang, Fei Wang*. Identification of small molecule activators of the Janus kinase/signal transducer and activator of transcription pathway using a cell-based screening. Biological & Pharmaceutical Bulletin, 2012, 35 :65-71.  

　　9. Danfeng Lu, Lijuan Yang, Qilin Li, Xiaoping Gao, Fei Wang*, Guolin Zhang*. Egonol gentiobioside and egonol gentiotrioside from Styrax perkinsiae promote the biosynthesis of estrogen by aromatase. European Journal of Pharmacology, 2012, 691: 275-282.  

　　10. Dan-feng Lu, Li-juan Yang, Fei Wang*, Guolin Zhang*. Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). Journal of Agricultural and Food Chemistry, 2012, 60: 8411-8418.  

　　11. Qianfeng Chen, Lijuan Yang, Guolin Zhang*, Fei Wang*. Bioactivity-guided isolation of antiosteoporotic compounds from Ligustrum lucidum. Phytotherapy Research, 2012, DOI：10.1002/ptr.4820. 

　　12. Lei Hua, Ya Li, Fei Wang, Dan-feng Lu, Kun Gao. Biologically active steroids from the aerial parts of Vernomia anthelmintica Wild. Fitoterapia, 2012, 83:1036-1041.  

　　13. Lijuan Yang, Danfeng Lu, Jiajia Guo, Xianli Meng, Guolin Zhang*, Fei Wang*. Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19). Journal of Ethopharmacology, 2012. DOI: 10.1016/j.jep.2012.11.031. 

　　14. Han-wei Liu, Xiu-zhu Yu, Daniele Padula, Gennaro Pescitelli, Zhi-wei Lin, Fei Wang, Kai Ding, Ming Lei, Jin-ming Gao. Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity. European Journal of Medicinal Chemistry,2013, 59: 265-273. 

　　15.Pu-zhao Zhang, Fei Wang, Li-juan Yang, Guo-lin Zhang. Pregnane alkaloids from Sarcococca hookeriana var. digyna. Fitoterapia, 2013, 89:143-148.  

　　16. Yuan Lin, Fei Wang, Li-juan Yang, Ze Chun, Jin-ku Bao, Guolin Zhang*. Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum. Phytochemistry 2013, 95: 242-251.  

　　17. 郭加加，黄君梅，王飞*。 冰乙酸水解法提高女贞子提取物中红景天苷含量。 《应用与环境生物学报》 2013, 19:723-726. 

　　18. 鲁丹枫，Azimova Bahtigul Jovliqizi, 张国林，王飞*。 采用磁微粒酶联免疫法构建基于KGN细胞的雌激素生物合成筛选模型。《天然产物研究与开发》 2013，25:27-30. 

　　19. Jin-Bao Xu, Yuan Lin, Shi-Hui Dong, Fei Wang, Jian-Min Yue*. Trichinenlides A-T, Mexcicanolide-Type Limonoids from Trichilia sinensis. Journal of Natural Products 2013, 76: 1872-1880. 

　　20. Zhengfu Tai, Yuan Lin, Yujiao He, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*, Fei Wang*. Luteolin Sensitizes the Antiproliferative Effect of Interferon / by Activation of Janus Kinase/Signal Transducer and Activator of Transcription Pathway Signaling through Protein Kinase A-Mediated Inhibition of Protein Tyrosine Phosphatase SHP-2 in Cancer Cells. Cellular Signalling 2013, DOI:10.1016/j.cellsig.2013.11.039.

　　21. Boyang Hu, Hai Zhang, Xianli Meng, Fei Wang*, Ping Wang*. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. Journal of Ethnopharmacology 2014, 153: 846-853. 

　　22. Chunyan Yang, Fu Li, Baowen Du, Fei Wang*, Mingkui Wang*. Isolation and characterization of new phenolic compounds with estrogen biosynthesis-inhibiting and antioxidation activities from Broussonetia papyrifera leaves. PLoS ONE. 2014. 9: e94198. 

　　23. Jiajia Guo, Yun Yuan, Danfeng Lu, Baowen Du, Liang Xiong, Jiangong Shi, Wanli Liu, Lijuan Yang, Xiaohong Yuan, Guolin Zhang*, Fei Wang*. Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3 ,5 ,8 -triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19). Toxicology and Applied Pharmacology. 2014. DOI: 10.1016/j.taap.2014.05.008. 

　　24. Liling Xu, Gen Li, Jing Wang, Yilin Fan, Zhengpeng Wan, Shaosen Zhang, Samina Shaheen, Jing Li, Li Wang, Cai Yue, Yan Zhao, Fei Wang, Joseph Brzostowski, Ying-Hua Chen, Wenjie Zheng, Wanli Liu. Through an ITIM-independent mechanism the Fc RIIB blocks B cell activation by disrupting the colocalized microclustering of the B cell receptor and CD19. Journal of Immunology 2014, 192:5179-5191. 

　　25. 袁韵，林之蔚，郭加加，王飞，袁小红。细胞膜结合的雌激素受体的特异性标记。《应用与环境生物学报》2014，20:227-232. 

　　26. Nilubon Sornkaew, Yuan Lin, Fei Wang, Guolin Zhang, Ratchanaporn Chokchaisiri, Ailian Zhang, Kanjana Wongkrajang, Parichart Suebsakwong, Pawinee Piyachaturawat, Apichart Suksamrarn. Diarylheptanoids of Curcuma comosa with Inhibitory Effects on Nitric Oxide Production in Macrophage RAW 264.7 Cells. Natural Product Communications 2015, 10:89-93. 

　　27. Yingyue Zeng, Junyang Yi, Zhengpeng Wan, Kai Liu, Ping Song, Alicia Chau, Fei Wang,  Zai Chang, Weidang Han, Wenjie Zheng, Ying-Hua Chen, Chunyang Xiong, Wanli Liu. Substrate stiffness regulates B-cell activation, proliferation, class switch, and T-cell-independent antibody responses in vivo. European Journal of Immunology 2015, 45: 1621-1634. 

　　28. Ce Liu, XingWang Zhao,  LiLing Xu, JunYang Yi, Samina Shaheen, Weidong Han, Fei Wang, Wenjie Zheng, Chenqi Xu, Wanli Liu. A negative-feedback function of PKC in the formation and accumulation of signaling-active B cell receptor microclusters within B cell immunological synapse. Journal of Leukocyte Biology 2015, 97:887-900. 

　　29. Zhengpeng Wan, Xiangjun Chen, Haodong Chen, Qinghua Ji, Yingjia Chen, Jing Wang, Yiyun Cao, Fei Wang, Jizhong Lou, Zhuo Tang, Wanli Liu. The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold. eLife 2015, 4:e06925. 

　　30. 邓腾，杨莉娟，罗国勇，李晟，杜宝文，王飞*。蛋白酪氨酸磷酸酶SHP2抑制剂体外筛选模型的建立及应用。《应用与环境生物学报》2015，21:602-606. 

　　31. Wei-Hua Wang, Yin Nian, Yu-Jiao He, Luo-Sheng Wan, Ni-Man Bao, Guo-Lei Zhu, Fei Wang*, Ming-hua Qiu*. New cycloartane triterpenes from the aerial parts of Cimicifuga heracleifolia. Tetrahedron 2015, 71:8018-8025. 

　　32. Yujiao He, Junmei Huang, Ping Wang, Sheng Li, Lijuan Yang, Apichart Suksamrarn, Wanli Liu, Guolin Zhang* and Fei Wang*.  Emodin potentiates the antiproliferative effect of Interferon / by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. Oncotarget 2015, DOI: 10.18632/oncotarget.6616. 

　　33. Guoyong Luo, Qi Ye, Baowen Du, Fei Wang, Guo-lin Zhang,Yinggang Luo. Iridoid Glucosides and Diterpenoids from Caryopteris glutinosa. Journal of Natural Products 2016. 79: 886–893. 

　　34. Lian-qi Chen, Xiao-fei Shen, Bo-yang Hu, Yuan Lin, Ighodaro Igbe, Cheng-gang Zhang, Guo-lin Zhang, Xiao-hong Yuan*, Fei Wang*. Nitric oxide production inhibition and mechanism of phenanthrene analogs in lipopolysaccharide-stimulated RAW264.7 macrophages. Bioorganic & Medicinal Chemistry Letters 2016, 26:2521-2525. 

　　35. Jiasi Wu, Hai Zhang, Boyang Hu, Lijuan Yang, Ping Wang, Fei Wang*, Xianli Meng*. Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. European Journal of Pharmacology 2016. 780: 106-114. 

　　36. Zhong-Hua Gao, Yi-Ming Shi, Zhe Qiang, Xia Wang, Shan-Zhai Shang, Yan Yang, Bao-Wen Du, Hui-Pan Peng, Xu Ji, Honglin Li*, Fei Wang*, Wei-Lie Xiao*. Plasiatine, an Unprecedented Indole–Phenylpropanoid Hybrid from Plantago asiatica as a Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2. Scientific Reports 2016 6:24945. 

　　37. Sheng Li,Li-juan Yang,Ping Wang,Yu-jiao He,Jun-mei Huang,Han-wei Liu,Xiao-fei Shen, Fei Wang*. Dietary apigenin potentiates the inhibitory effect of interferon- on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation. Food & Nutrition Research 2016, 60:31288. 

　　38. Wenchen Pu , Yun Yuan , Danfeng Lu, Xin Wang , Hanwei Liu, Chun Wang, Fei Wang, Guolin Zhang*. 2-Phenylbenzo[b]furans: Synthesis and promoting activity on estrogen biosynthesis. Bioorganic & Medicinal Chemistry Letters 2016, 26: 5497–5500.  

　　39. Samina Shaheen, Zhengpeng Wan, Zongyu Li, Alicia Chau, Xinxin Li, Shaosen Zhang, Yang Liu, Junyang Yi, Yingyue Zeng, Jing Wang, Xiangjun Chen, Liling Xu, Wei Chen, Fei Wang, Yun Lu, Wenjie Zheng, Yan Shi, Xiaolin Sun, Zhanguo Li, Chunyang Xiong, Wanli Liu. Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKC and focal adhesion kinase. eLife 2017, 6:e23060.  

　　40. Fu Li, Bao-Wen Du, Dan-Feng Lu, Wen-Xuan Wu, Kanjana Wongkrajang, Lun Wang, Wen-Chen Pu, Chang-Lu Liu, Han-Wei Liu, Ming-Kui Wang*, Fei Wang*. Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects. Scientific Reports 2017, 7:7760.  

　　41. Orawan Wonganan, Yu-jiao He, Xiao-fei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guo-lin Zhang*, Fei Wang*. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside   potentiates the anti-proliferative effect of interferon / by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicology and Applied Pharmacology 2017, 336: 31-39.  

　　42. Ighodaro Igbe, Xiao-fei Shen, Wei Jiao, Zhe Qiang, Teng Deng, Sheng Li, Wan-li Liu, Han-wei Liu, Guo-lin Zhang, Fei Wang*. Dietary quercetin potentiates the antiproliferative effect of interferon- in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. Oncotarget 2017, 8: 113734-113748.  

　　43. Xiaojuan Han, Honghan Chen,Jiao Zhou, Haoran Tai, Hui Gong,Xiaobo Wang, Ning Huang, Jianqiong Qin, Tingting Fang, Fei Wang, Hengyi Xiao. The inhibitory effect of Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration. Journal of Cellular Physiology 2018, 233: 3945-3954.  

　　44.  Guidong Gong, Yuan Cao, Fei Wang*, Gang Zhao*. Planar chiral ferrocene cyclopalladated derivatives induce caspase-dependent apoptosis and antimetastasis in cancer cells. Organometallics 2018. 37: 1103-1113.  　　  

　　45. Guidong Gong, Yuan Cao, Hongyun Qian, Yangyang Zhou, Haihang Zhao, Lin Li, Fei Wang*, Gang Zhao*. Assessment of the antitumor activity of a cyclopalladated ferrocene compound assisted by a dual-targeting drug delivery system. Chemical Communications 2018, 54: 8312-8315. 

　　46. Jean-Bosco Jouda, Emmanuel Mfotie Njoya, C line Djama Mbazoa, ZongYuan Zhou, Alain Meli Lannang*, Jean Wandji, Yoshihito Shiono, Fei Wang*. Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF- B signaling pathways. Bioorganic Chemistry 2018, 80: 216-222. 

　　47. Junyi Wang, Feng Lin, Zhengpeng Wan, Xiaolin Sun, Yun Lu, Jianyong Huang, Fei Wang, Yingyue Zeng, Ying-Hua Chen, Yan Shi, Wenjie Zheng, Zhanguo Li, Chunyang Xiong, and Wanli Liu. Profiling the origin, dynamics, and function of traction force in B cell activation. Science Signaling 2018, 11: eaai9192. 

　　48. De-Bing Pu, Bao-wen Du, Wen Chen, Jun-bo Gao, Kun Hu, Nan Shi, Yi-ming Li, Xing-jie Zhang, Ruihan Zhang, Xiao-Nian Li, Hongbin Zhang, Fei Wang*, Wei-Lie Xiao*. Premnafulvol A: a Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and its Biosynthetically Related Analogues from Premna fulva. Organic Letters 2018, 20:6314-6317.  

　　49. Azubuike P. Ebokaiwe, Omamuyovwi M. Ijomone, Sharon O. Osawe,Chukwuma J. Chukwu, Chukwunonso E.C.C. Ejike, Guolin Zhang, Fei Wang. Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus. Redox Report 2018, 23:194-205. 

　　50. Zhe Qiang, Zong-yuan Zhou, Ting Peng, Pu-zi Jiang, Nan Shi, Emmanuel Mfotie Njoya, Bahtigul Azimova, Wan-li Liu, Wei-hua Chen, Guo-lin Zhang*, Fei Wang*. Inhibition of TPL2 by interferon- suppresses bladder cancer through activation of PDE4D. Journal of Experimental & Clinical Cancer Research 2018, 37:288. 

     51. Rui Li, Fang Liu, Xiao Yang, Lian-qi Chen, Fei Wang, Guo-lin Zhang, Qian Zhang, Liang Zhang, Yu-xin He, Yu-feng Li, Peng Lai, Xiang-gui Chen, Min Ye, Hong-tao Xiao, Hang Xiao. Analysis of bisabolocurcumin ether (a terpene-conjugated curcuminoid) and three curcuminoids in Curcuma species from different regions by UPLC-ESI MS/MS and their in vitro anti-inflammatory activities. Journal of Functional Foods 2019, 52: 186-195. 

　　 52 . 李晟，李炎鑫，Emmanuel Mfotie Njoya, 蒋黎，李霖*，王飞*。瑞香素及噁唑类小分子抑制吲哚胺-2，3-双加氧酶1（IDO1)的研究。天然产物研究与开发 2018， 30：2128-2132. 

　　 53 . Zhengpeng Wan,  Chenguang Xu, Xiangjun Chen,  Hengyi Xie, Zongyu Li, Jing Wang, Xingyu Ji, Haodong Chen, Qinghua Ji, Samina Shaheen, Yang Xu, Fei Wang, Zhuo Tang,  Ji-Shen Zheng, Wei Chen, Jizhong Lou, Wanli Liu. PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation. Journal of Cell Biology. 2018, 217: 2565-2582. 

　　 54 . Lingling Yang, Yang Chen, Junlin He, Emmanuel Mfotie Njoya, Jianjun Chen, Siyan Liu, Congqiang Xie, Wenze Huang, Fei Wang, Zhouyu Wang, Yuzhi Li, Shan Qian. 4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors. Bioorganic & Medicinal Chemistry 2019.27: 1087-1098. 

　　 55 . Gertrude Laura Foudjo Melacheu, Emmanuel Mfotie Njoya, Jean-Bosco Jouda, Brussine Nadege Wakeu Kweka, C line Djama Mbazoa, Fei Wang, Jean Wandji. Two new indole alkaloids from Tabernaemontana contorta Stapf. Phytochemistry Letters 2019, 30:116-119. 

　　 56 . Jiasi Wu, Yu Luo, Qing Jiang, Sheng Li, Wenge Huang, Li Xiang, Deming Liu, Yingfan Hu, Ping Wang, Xiaoxia Lu, Guolin Zhang, Fei Wang*, Xianli Meng*. Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1. Pharmacological Research 2019. 147: 104348. 

　　 57 . Gertrude Foudjo Melacheu Laura, Emmanuel Mfotie Njoya, Jean-Bosco Jouda, Brussine Nadege Wakeu Kweka, Celine Djama Mbazoa, Fei Wang, Elisabeth Seguin, Jean Wandji. A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf. Natural Product Research 2019. DOI:doi: 10.1080/14786419.2019. 

　　 58 . Xingwang Zhao, Hengyi Xie, Meng Zhao, Asma Ahsan, Xinxin Li, Fei Wang, Junyang Yi, Zhiyong Yang, Chuan Wu, Indu Raman, Quan-Zhen Li, Tae Jin Kim, Wanli Liu. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function. Science Advances 2019; 5: eaaw0315. 

　　 59 . Pu-Zhao Zhang, Ya-Mei Zhang, Yuan Lin, Fei Wang, Guo-Lin Zhang. Three new diterpenes from Dysoxylum lukii and their NO production inhibitory activity. Journal of Asian Natural Products Research. 2019. DOI: 10.1080/10286020.2019.1607839. 

　　 60 . Xin Huang, Yongyun Zhao, Qinlin Pu, Getong Liu, Yan Peng, Fei Wang, Gangyi Chen, Meiling Sun, Feng Du, Juan Dong, Xin Cui, Zhuo Tang, Xianming Mo. Intracellular selection of trans-cleaving hammerhead ribozymes. Nucleic Acids Research 2019, 47:  2514–2522. 

　　 61 . Puzhao Zhang, Yuan Lin, Fei Wang, Dongmei Fang, Guolin Zhang. Diterpenes from Dysoxylum lukii Merr. Phytochemistry Letters 2019, 29: 53-56. 

　　 62 . 史楠，史小可，Jovliqizi Azimova Bahtigul, Abduvaliev Anvar, Rakhmanov Alisher, 王飞*。 Eryxin通过抑制芳香化酶表达调控雌激素生物合成。《应用与环境生物学报》 2019， 25： 1205-1210。 

　　 63 . De-ming Liu, Dong Yang, Chun-yan Zhou, Jia-si Wu, Guo-lin Zhang, Ping Wang, Fei Wang*, Xian-li Meng*. Aloe-emodin induces hepatotoxicity by the inhibition of multidrug resistance protein 2. Phytomedicine 2020, 68: 153148. 

　　 64 . Bao-Wen Du, Xing-Jie Zhang, Nan Shi, Ting Peng, Jun-Bo Gao, Bahtigul Azimova, Ruihan Zhang, De-Bing Pu, Chun Wang, Anvar Abduvaliev, Alisher Rakhmanov, Guo-Lin Zhang, Wei-Lie Xiao*, Fei Wang*. Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). European Journal of Pharmacology 2020, 879: 173154. 

　　 65 . Dongmei Wang, Yun Yang, Xiaoke Shi, Kaitai Yang, Kaipu Yin, Fei Wang, Guolin Zhang, Yinggang Luo. Viburnumfocesides A–D, 1-O-isovaleroylated iridoid 11-O-alloside derivatives from Viburnum foetidum var. ceanothoides. Fitoterapia 2020, 143:104601. 

　　 66 . Jean-Bosco Jouda*, Emmanuel Mfotie Njoya, Serge Alain Tanemossu Fobofou, Zong Yuan Zhou, Zhe Qiang, C line Djama Mbazoa, Wolfgang Brandt, Guo-lin Zhang, Jean  Wandji, Fei Wang*. Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp.CAM212 with a Semisynthetic Derivative Downregulating the ERK/I B Signaling Pathways. Planta Medica. 2020, 86: 1032-1042. 

　　 67 . Azubuike Peter Ebokaiwe, Emmanuel Mfotie Njoyaa, Yuwen Sheng, Zhonghui Zhang, Li Sheng, Zongyuan Zhou, Zhe Qiang, Peng Ting, Ahmed A. Hussein, Guolin Zhang, Xiaoxia Lu, Lin Li*, Fei Wang*. Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells. Toxicology & Applied Pharmacology 2020, 404: 115203.  

　　 68 . Xufan Lian, Xiuli Zhang, Fei Wang, Xiaoning Wang, Zheyong Xue, Xiaoquan Qi. Characterization of a 2,3-oxidosqualene cyclase in the toosendanin biosynthetic pathway of  Melia toosendan. Physiologia Plantarum. 2020, 170: 528-536. 

　　 69 . Xuejian Zhang, Ting Peng, Xiaoke Shi, Dongmei Fang, Lin Tang, Fang Chen, Fei Wang, Guolin Zhang, Yinggang Luo. Diterpenoids caryopterisoids D-Q and iridoid glucoside derivatives caryopterisides F-H from Caryopteris glutinosa. Phytochemistry 2020, 180: 112534. 

　　 70 . Wei Xiong, Xiaohong Wang, Xianyan Shen, Cuifang Hu, Xin Wang, Fei Wang, Guolin Zhang, Chun Wang. Synthesis of flavonols via pyrrolidine catalysis: origins of the selectivity for flavonol versus aurone. Journal of Organic Chemistry 2020, 85, 13160？13176. 

　　 71 . Jian Xu, Runze Li,Nian Xu, Xiaohua Liu*, Fei Wang*, Xiaoming Feng*. Enantioselective  4+2 . cycloaddition/cyclization cascade reaction and total synthesis of cis-Bis (cyclotryptamine) alkaloids. Organic letters. 2021, 23: 1856-1861. 

　　 72 . Zhonghui Zhang, Guoyuan Du, Guidong Gong, Yuwen Sheng, Xiangyu Lu, Wentao Cai, Fei Wang*, Gang Zhao*. A novel ferrocene-palladium metal complex: synthesis, single crystal structure, in vitro cytotoxicity study and molecular docking. Journal of Molecular Structure 2021, 1232:130021. 

　　 73 . Wisanee Wisanwattana#, Kanjana Wongkrajang#, Dong-yi Cao, Xiao-ke Shi, Zhong-hui Zhang, Zong-yuan Zhou, Fu Li, Qing-gang Mei, Chun Wang, Apichart Suksamrarn, Guo-lin Zhang*, Fei Wang*. Inhibition of phosphodiesterase 5 promotes the aromatase- mediated estrogen biosynthesis in osteoblastic cells by activation of cGMP/PKG/SHP2 pathway. Frontiers in endocrinology 2021, 12: 636784.. 

　　 74 . 史小可，李晟，付乃洁，曹东怡， 王飞*。 腺苷酸环化酶抑制剂体外筛选模型的建立及应用。 《应用与环境生物学报》2021, 27:185-190. 

　　 75 . Ting Peng, Orawan Wonganan, Zhonghui Zhang, Jialing Yu, Ruiying Xi, Yu Cao,Apichart Suksamrarn, Guolin Zhang*, Fei Wang*. A 2-benzylmalonate derivative as STAT3 inhibitor suppresses tumor growth in hepatocellular carcinoma by upregulatin -TrCP E3 ubiquitin ligase. International Journal of Molecular Sciences 2021, 22:3354. 

     76 . Zongyuan Zhou#, Yiming Li#, Xiaofang Ma#, Biyun Cao, Ting Peng, Yuwen Sheng, Huipan Peng, Runze Li, Yu Cao, Ruiying Xi, Fu Li, Mengru Wang, Handong Sun, Guolin Zhang, Hongbin Zhang*, Kaifeng Hu*, Weilie Xiao*, Fei Wang*. Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma. Journal of Medicinal Chemistry 2021, 64:7404–7421.

     77.Xuejian Zhang, Guoyong Luo, Yu Cao, Dumaa Mishig, Munkhgerel Lodonjav,Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang*, Yinggang Luo*. ( )-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa. Bioorganic Chemistry 2021, 116: 105364. 

　　78.Xiao-Yu Hou, Yu Cao, Bing-Lan Wu, Bin Chen, Fu Li, Fei Wang, Ming-Kui Wang, Lun Wang. New 2-isobutylmalates from the tubers of Bletilla striata and their potential anti-pulmonary fibrosis activities. Phytochemistry Letters2021, 46: 95-99. 

　　79.Yuwen Sheng#, Yuwen Chen#, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang*, Wei Jiao*, Fei Wang*. Identi？cation of pyruvate carboxylase as the cellular target of natural bibenzyls with potent anticancer activity against hepatocellular carcinoma via metabolic reprogramming. Journal of Medicinal Chemistry 2022, 65: 460-484. 

　　80.Guidong Gong, Jiezhou Pan, Yunxiang He, Jiaojiao Shang, Xiaoling Wang,Yaoyao Zhang, Guolin Zhang, Fei Wang*, Gang Zhao*, Junling Guo*. Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy. Theranostics 2022, 12: 2028-2040.  

　　81.Bing Yang, Zhen Zhang, Xiangjun Chen, Xu-Yan Wang, Shishang Qin, Liaoqi Du, Changjiang Yang, Liyu Zhu, Wenbo Sun, Yongjie Zhu, Qinwen Zheng, Shidong Zhao, Quan Wang, Long Zhao, Yilin Lin, Jinghe Huang, Fan Wu, Lu Lu, Fei Wang, Wenjie Zheng, Xiao-Hua Zhou, Xiaozhen Zhao, Ziye Wang, Xiaolin Sun, Yingjiang Ye, Shan Wang, Zhanguo Li, Hai Qi, Zemin Zhang, Dong-Ming Kuang, Lei Zhang, Zhanlong Shen*, Wanli Liu*. An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. Journal of Clinical Investigation. 132: e153454. 

　　82.Dong-yi Cao, Zhong-hui Zhang, Run-ze Li, Xiao-ke Shi, Rui-ying Xi, Guo-lin Zhang, Fu Li*, Fei Wang*. A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation.Immunology Letters 2022. 244: 28-39. 

    83.Nai-jie Fu, Rui-ying Xi, Xiao-ke Shi, Run-ze Li, Zhong-hui Zhang, Ling-yu Li, Guo-lin Zhang*, Fei Wang*. Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways. Toxicology and Applied Pharmacology 2022, 441: 115988. 

    84.席芮颖，付乃洁，李润择， 张国林， 王飞*。 氯氰碘柳胺钠通过抑制蛋白酪氨酸磷酸酶SHP2诱导RAS突变型肺癌细胞衰老和死亡。《应用与环境生物学报》2022, 28: 365-371。 

    85.Yuan Lin#, Kanjana Wongkrajang#, Xiaofei Shen#, Ping Wang, Zongyuan Zhou, Thipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn*, Guolin Zhang*, Fei Wang*. Discovery of diarylheptanoids that activate 7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorganic & Medicinal Chemistry 2022, 66: 116811. 

    86.Ting Peng#, Yujiao He#, Tao Wang#, Jialing Yu#, Xiaofang Ma#, Zongyuan Zhou, Yuwen Sheng, Lingyu Li,Huipan Peng, Sheng Li, Jiawei Zou, Yi Yuan, Yongyun Zhao, Hailong, Shi, Fu Li, Wanli Liu, Kaifeng Hu*, Xiaoxia Lu*, Guolin Zhang*, Fei Wang*. Discovery of a novel small-molecule inhibitor disrupting TRBP-Dicer interaction against hepatocellular carcinoma via the modulation of microRNA biogenesis. Journal of Medicinal Chemistry 2022, 65, 11010？11033. (封面论文) 

    87.李润择, 曹东怡, 张中辉, 李晟, 吴嘉思, 王飞*.半胱氨酸天冬氨酸蛋白水解酶caspase-1抑制剂体外筛选模型的构建及应用. 《应用与环境生物学报》2022, 28: 631-637 

    88.Xuejian Zhang, Yu Cao, Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang, Yinggang Luo. Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa. Phytochemistry 2022, 203: 113378. 

    89.Jiasi Wu, Yuejia Lan, Xiaoke Shi , Wenge Huang, Sheng Li, Jizhou Zhang, Huan Wang , Fei Wang*, Xianli Meng*. Sennoside A is a novel inhibitor targeting caspase-1. Food & Function 2022. 13: 9782-9795.