科研成果
| 论文编号: | DOI: 10.1002/adsc.200700504 |
| 第一作者所在部门: | 天然产物研究中心 |
| 论文题目: | Rationally-Designed S-Chiral Bissulfinamides as Highly Enantioselective Organocatalysts for Reduction of Ketimines |
| 作者: | 裴东 |
| 全部作者: | Dong Pei,Yu Zhang,Siyu Wei,Meng Wang,Jian Sun |
| 论文出处: | |
| 刊物名称: | Advanced synthesis & catalysis |
| 年: | 2008 |
| 卷: | 350 |
| 期: | 4 |
| 页: | 619-623 |
| 联系作者: | 孙健 |
| 收录类别: | |
| 影响因子: | 5.619 |
| 摘要 : | We recently reported the first example of S-chiral organocatalysts, that are highly efficient and enantioselective in substoichometric amounts, and which use a chiral monosulfinamide group as Lewis base to activate trichlorosilane (HSiCl3) to reduce N-arylketimines. A plausible mechanism involving two molecules of the monosulfinamde catalyst for the activation of HSiCl3 prompted us to design S-chiral bissulfinamides as new catalysts. We herein describe our findings that an easily prepared S-chiral bissulfinamide bearing a five-methylene linkage not only inherited the excellent substrate generality from the monosulfinamide catalysts, but also exhibited further improved enantioselectivity. |
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