科研成果
| 论文编号: | DOI: 10.1002/jms.1273 |
| 第一作者所在部门: | 天然产物研究中心 |
| 论文题目: | Negative electrospray ionization tandem mass spectrometric investigation of ent-kaurane diterpenoids from the genus Isodon |
| 作者: | 周燕 |
| 全部作者: | Yan Zhou,Sheng-Xiong Huang,Li-Mei Li,Jing Yang,Xin Liu,Shu-Lin Peng,Li-Sheng Ding,Han-Dong Sun |
| 论文出处: | |
| 刊物名称: | JOURNAL OF MASS SPECTROMETRY |
| 年: | 2008 |
| 卷: | 43 |
| 期: | 1 |
| 页: | 63-73 |
| 联系作者: | 丁立生，孙汉董 |
| 收录类别: | |
| 影响因子: | 2.94 |
| 摘要 : | ent-Kaurane diterpenoids are a class of natural compounds isolated from genus Isodon, which have been found to have important bioactivities. Negative electrospray ionization tandem mass spectrometry ((−)ESI-MSn) was used to investigate the fragmentation pattern of C-20-nonoxygenated ent-kauranes and two subtypes of C-20-oxygenated ent-kauranes by using an ion trap instrument and accurate mass measurement on an ESI-Q-time-of-flight (TOF)mass spectrometer. The analysis revealed that loss of CH2O or CO2 is the predominant process for 7, 20-epoxy and 7, 20 : 14, 20-diepoxy subgroup of C-20-oxygenated ent-kauranes. In addition, compounds of C-20-nonoxygenated ent-kauranes with a conserved core structure but different substituent groups, such as a hydroxyl, aldehyde, carboxyl, and acetyl moiety, resulted in diagnostic product ions through losses of H2O, CO, CO2, and AcOH, respectively. This work clearly demonstrates the utility of tandem mass spectrometry for studies on the rationalization of the diagnostic fragmentation of a series of compounds from two main types of the ent-kaurane diterpenoids. |
| 英文摘要 : | |
| 外单位作者单位 : | |
| 备注 : | |