科研成果
| 论文编号: | |
| 第一作者所在部门: | 天然产物研究中心 |
| 论文题目: | Studies on the Reactions of 2,3-Diketopyrido [4,3,2-de] quinolines with Amino Alcohols |
| 作者: | 邵华武 |
| 全部作者: | 邵华武 |
| 论文出处: | |
| 刊物名称: | 第七届全国天然有机化学学术研讨会论文集，成都,2008年9月 |
| 年: | 2008 |
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| 期: | |
| 页: | 126-126 |
| 联系作者: | 邵华武 |
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| 摘要 : | Marine organisms a rich and valuable source of natural products . Marine nature products , as a field of scientific endeavor , have hence grown considerably . Many metabolites have been isolated from marine sources,1-2 which have generated interest both as challenging problems for structure elucidation and synthesis , as well as for their biological activities .3-8 The Dercitin exhibits immunosuppressant activity .9-10 These alkaloids contain a pyrido [4,3,2-de]quinoline core structure . The biological evaluation data show that 1-ethoxycarbornylmethyl-2,3-diketopyrido[4,3,2-de] quinoline is actively cytotoxic exhibiting a wide spectrum of aniticancer activities against 22 cell lines.We heein describe the novel amination and elimination reaction that occurs between 2,3-diketopyrido[4,3,2-de]quinolines and various amino alcohols. |
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