科研成果
| 论文编号: | DOI: 10.1002/chem.200801582 |
| 第一作者所在部门: | 天然产物研究中心 |
| 论文题目: | Highly Enantioselective Synthesis of β-Amino Acid Derivatives by the Lewis Base Catalyzed Hydrosilylation of β-Enamino Esters |
| 作者: | Hong-Jie Zheng |
| 全部作者: | Hong-Jie Zheng,Wen-Bing Chen,Zhi-Jun Wu,Jin-Gen Deng, Wen-Qing Lin,Wei-Cheng Yuan,Xiao- Mei Zhang |
| 论文出处: | |
| 刊物名称: | Chemistry A European Journal |
| 年: | 2008 |
| 卷: | 14 |
| 期: | 32 |
| 页: | 9864-9867 |
| 联系作者: | Xiao- Mei Zhang |
| 收录类别: | |
| 影响因子: | 5.454 |
| 摘要 : | Aryl substitute makes it different:A new general enantioselective hydrosilylation of N-aryl β-enamino esters with trichlorosilane has been developed (see scheme). The N-aryl substituent is crucial for the activity and enantioselectivity. In the presence of catalytic amount of readily accessible chiral N-picolinoylpyrrolidine derivatives, the reactions proceeded smoothly to provide various chiralβ-amino esters in good yields (≤97 %) and moderate to excellent enantioselectivities (≤96 % ee). |
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