Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethyl-phenyl)- 4-Alkyl-1H-[1,2,3]-Triazoles
稿件作者：胡华男
通讯作者：张安将，丁立生
刊物名称：Molecules
发表年份：2008
卷：13
期：3
页码：556-566
影响因子：1.252
文章摘要：
A new and efficient method for the synthesis of 1-(2,6-dichloro-4-trifluoromethylphenyl)-
4-alkyl-1H-[1,2,3]-triazoles by the room temperature 1,3-dipolar cycloaddition of (2-azido-1,3-dichloro-5-trifluoromethyl)benzene with terminal alkynes in the presence of Cu (I) salt as catalyst is reported. All the reactions gave 1,4-disubstituted products with high regioselectivity, as no 1,5-disubstituted product was formed. The structures of all the title compounds have been confirmed by elemental analysis, 1H- and 13C-NMR and in addition, the structure of compound 5a was investigated by X-ray crystallography.
4-alkyl-1H-[1,2,3]-triazoles by the room temperature 1,3-dipolar cycloaddition of (2-azido-1,3-dichloro-5-trifluoromethyl)benzene with terminal alkynes in the presence of Cu (I) salt as catalyst is reported. All the reactions gave 1,4-disubstituted products with high regioselectivity, as no 1,5-disubstituted product was formed. The structures of all the title compounds have been confirmed by elemental analysis, 1H- and 13C-NMR and in addition, the structure of compound 5a was investigated by X-ray crystallography.
