Marine organisms a rich and valuable source of natural products . Marine nature products , as a field of scientific endeavor , have hence grown considerably . Many metabolites have been isolated from marine sources,1-2 which have generated interest both as challenging problems for structure elucidation and synthesis , as well as for their biological activities .3-8 The Dercitin exhibits immunosuppressant activity .9-10 These alkaloids contain a pyrido [4,3,2-de]quinoline core structure . The biological evaluation data show that 1-ethoxycarbornylmethyl-2,3-diketopyrido[4,3,2-de] quinoline is actively cytotoxic exhibiting a wide spectrum of aniticancer activities against 22 cell lines.We heein describe the novel amination and elimination reaction that occurs between 2,3-diketopyrido[4,3,2-de]quinolines and various amino alcohols.